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Many patients report reduced discomfort or improved function within 1-2 weeks

128 Introduction of a W104A mutation in the fused GHBP prevented intra- and inter-molecular binding

1D, the vibrational peaks observed at ~3345 cm 1 , 1671 cm 1 , 1622 cm 1 , and 1436 cm 1 can be attributed to the presence of hydroxyl groups, carboxyl groups, N-H bonds, and C-H bonds, respectively [23]